Sodium hyaluronateiboneka cyane mu nyamaswa n'abantu ibintu bifatika bifatika, muruhu rwumuntu, amazi ya synovial, umugozi, urwenya rwamazi, hamwe numubiri wa vitreous ophthalmic. Uburemere bwa molekile ni 500 000-730 000 Dalton. Igisubizo cyacyo gifite viscoelasticitike kandi yerekana umwirondoro. Nibisobanuro byokubaga amaso. Igumana ubujyakuzimu runaka bwimbere yimbere nyuma yo guterwa mucyumba cyimbere. Nibyiza gukora. Irinda kandi corneal endothelial selile hamwe nuduce twimbere, igabanya ibibazo bikora, kandi igatera gukira ibikomere.
Inkomoko ya Sodium hyaluronate
Sodium hyaluronateni macromolecule polysaccharide yakuwe mumubiri wa bovine vitreous. Ifite ibintu bitatu biranga: kurwanya gusaza no kubika ibintu bishya no gufata ibinyabuzima.
Sodium hyaluronate ni kimwe mu bigize uruhu rwabantu, ni mucosa ikwirakwizwa cyane mu mubiri, ibaho muri matrix ya tissue ihuza, kandi ifite ingaruka nziza.
Ibiranga Sodium hyaluronate
Sodium hyaluronate ifite ibintu bitatu biranga: kurwanya gusaza no kubika ibintu bishya hamwe na biotechnologiya. Sodium hyaluronate ni kimwe mu bigize uruhu rwabantu hamwe na mucose ikwirakwizwa cyane mumubiri wumuntu. Ibaho muri matrix ya tissue ihuza kandi ifite ingaruka nziza.
Inyungu za Sodium Hyaluronate
1. Kunoza imiti ya farumasi
Acide Hyaluronicnikintu nyamukuru kigize ingirabuzimafatizo nka interstitium yumuntu, umubiri wa vitreous, hamwe namazi ya synovial. Ifite ibiranga kubika amazi, kubungabunga umwanya udasanzwe, kugenzura umuvuduko wa osmotic, gusiga amavuta, no guteza imbere gusana selile muri vivo. Nkumutwara wibiyobyabwenge byamaso, birashobora kongera igihe cyo gufata ibiyobyabwenge hejuru yijisho byongera ubwiza bwibitonyanga byamaso, kunoza bioavailable yibiyobyabwenge, no kugabanya uburakari bwibiyobyabwenge kumaso.
Ubuvuzi bwa aduvant bushobora guterwa mu cyuho cya arctular nk'amavuta yo kuvura indwara ya rubagimpande, nko gutera inshinge.
2. Kureka Kurwanya
Urwego rwubushuhe bwuruhu rufitanye isano rya hafi nibirimo aside ya hyaluronike. Iyo imyaka igenda yiyongera, ibirimo aside aside ya hyaluronike mu ruhu bigabanuka, bigabanya imbaraga zo kubika amazi kuruhu kandi bikabyara iminkanyari. Sodium hyaluronate yumuti wamazi ufite viscoelasticité na lubricité. Iyo ushyizwe hejuru yuruhu, irashobora gukora firime yinjira kugirango igumane uruhu kandi rukayangane. Acide ntoya ya hyaluronike irashobora kwinjira muri dermis, igatera umuvuduko ukabije w'amaraso, igafasha uruhu kwinjiza intungamubiri, kandi ikagira uruhare mu buzima bwo kwisiga no kurwanya inkari.
3. Ingaruka nziza
Ingaruka yo gutanga amazi ninshingano zingenzi zasodium hyaluronate mu kwisiga. Ugereranije n’ibindi bitanga amazi, ubushuhe bugereranije bw’ibidukikije ntibigira ingaruka nke ku ngaruka zabwo. Iyi kamere idasanzwe ihujwe nuruhu mubihe bitandukanye, ubuhehere butandukanye bwibidukikije, nkubukonje bwizuba nimpeshyi itose, hamwe nibisabwa ningaruka zo kwisiga. Kugumana ubuhehere bwa sodium hyaluronate bifitanye isano n'uburemere bwacyo na molekile.
4. Ingaruka zimirire
Sodium hyaluronate ni ibinyabuzima bisanzwe mu ruhu, kandi sodium hyaluronate ya exogenous ni inyongera ya sodium hyaluronate ya endogenous mu ruhu. Sodium hyaluronate ifite ubuziranenge irashobora kwinjira muri epidermis yuruhu, igateza imbere imirire yuruhu no gusohora imyanda, bityo ikarinda gusaza kwuruhu, kandi ikagira uruhare mukwisiga ubwiza nubwiza. Kubungabunga uruhu ni ngombwa kuruta andi mavuta yo kwisiga kandi byahindutse icyifuzo cyabantu ba kijyambere cyo gukomeza ubwenge.
5. Gusana no gukumira ibyangirika byuruhu
Uruhu rutwikwa cyangwa rugatwikwa nizuba, nko gutukura, kwirabura, gukuramo, nibindi, cyane cyane nimirasire ya ultraviolet kumurasire yizuba. Sodium hyaluronate irashobora guteza imbere kuvugurura uruhu rwakomerekejwe no gukwirakwiza no gutandukanya ingirabuzimafatizo no kwanduza radicals idafite ogisijeni. Mbere yo gukoresha nayo ifite ingaruka zo gukumira. Uburyo bwibikorwa byayo buratandukanye na ultraviolet yinjiza ikunze gukoreshwa nizuba. Kubera iyo mpamvu, aside hyaluronic na ultraviolet yinjira mu bicuruzwa byita ku ruhu rwizuba bigira ingaruka zifatika, zishobora kugabanya kwanduza imirasire ya ultraviolet no gusana ibyangiritse ku ruhu biterwa n’umuriro muto wa ultraviolet, bityo bikagira uruhare runini rwo kurinda.
Gukomatanya kwa sodium hyaluronate na EGF (gukura kwa epidermal) birashobora kwihutisha kuvugurura ingirabuzimafatizo kandi bigatuma uruhu rworoha, rworoshye kandi rworoshye. Iyo uruhu rubabajwe no gutwikwa byoroheje no gutwika, gukoresha amavuta yo kwisiga arimo sodium hyaluronate hejuru birashobora kugabanya ububabare no kwihutisha gukira kwuruhu rwakomeretse.
6. Gusiga amavuta no gushiraho film
Sodium hyaluronate ni ubwoko bwa polymer bufite amavuta akomeye hamwe na firime. Ibicuruzwa byita ku ruhu birimo sodium hyaluronate bifite amavuta meza kandi byunvikana neza iyo ukoresheje. Iyo ushyizwe kuruhu, firime irashobora gukorwa hejuru yuruhu, bigatuma uruhu rwumva neza kandi rutose, kandi rukarinda uruhu. Ibicuruzwa byogosha umusatsi birimo sodium hyaluronate birashobora gukora igipande cya firime hejuru yumusatsi, ishobora gutobora, gusiga amavuta, kurinda umusatsi, gukuraho amashanyarazi ahamye, kandi bigatuma umusatsi woroshye guhuza, mwiza, na karemano.
7. Kubyimba
Sodium hyaluronate ifite ubukonje bwinshi mumuti wamazi. Irashobora kugira uruhare mu kubyimba no gutuza mu kwisiga.
8. Ingaruka za farumasi ya Sodium Hyaluronate
Ibintu bifatika bya physiologiya bibaho cyane mubikoko no mubantu kandi bikwirakwizwa muruhu rwabantu, amazi ya synovial yingingo, umugozi, urwenya rwamazi, numubiri wamaso. Uburemere bwa molekuline ni 500000-730000 Dalton. Igisubizo cyacyo gifite viscoelasticité no kwigana. Nibisobanuro byokubaga amaso. Igumana ubujyakuzimu runaka bwicyumba cyimbere nyuma yo guterwa mucyumba cyimbere, cyoroshye gukora. Irinda kandi ingirabuzimafatizo ya endoteliyale nuduce twimbere, igabanya ingorane, kandi igatera gukira ibikomere.
Igihe cyo kohereza: Kanama-23-2023
